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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:254496
Term: 7,12-dimethyltetraphene
Definition: A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.
Chemical ID: MESH:D015127
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTD9, 10-Dimethyl-1, 2-benzanthracene results in increased expression of CCND1 mRNA, 9, 10-Dimethyl-1, 2-benzanthracene results in increased expression of CCND1 protein

PMID:12097258, PMID:12376462
increases expressionISORGD:685566480464CTD9, 10-Dimethyl-1, 2-benzanthracene results in increased expression of CCND1 protein

PMID:29663660
increases expressionISORGD:685576480464CTD9, 10-Dimethyl-1, 2-benzanthracene results in increased expression of CCND1 mRNA

PMID:21785161
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.