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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:21759
Term: N-methyl-N'-nitro-N-nitrosoguanidine
Definition: An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position
Chemical ID: MESH:D008769
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccnd1increases expressionEXP 6480464CTDMethylnitronitrosoguanidine results in increased expression of CCND1 mRNA; Methylnitronitrosoguanidine results in increased expression of CCND1 proteinPMID:19851710 PMID:21628965
Ccnd1multiple interactionsEXP 6480464CTDEugenol inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of CCND1 mRNA]PMID:19851710
Ccnd1multiple interactionsISOCcnd1 (Mus musculus)6480464CTD[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of CCND1 proteinPMID:12135628
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