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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:17234
Term: glucose
Definition: An aldohexose used as a source of energy and metabolic intermediate.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDGlucose results in increased expression of CCND1 protein

PMID:24971582
multiple interactionsEXP 6480464CTDresveratrol inhibits the reaction [Glucose results in increased expression of CCND1 protein]

PMID:24971582
increases expressionISORGD:685566480464CTDGlucose results in increased expression of CCND1, Glucose results in increased expression of CCND1 mRNA

PMID:23690508, PMID:27049278
multiple interactionsISORGD:685566480464CTD[Glucose co-treated with resveratrol] results in decreased expression of CCND1 mRNA, resveratrol inhibits the reaction [Glucose results in increased expression of CCND1 mRNA]

PMID:24064760, PMID:27049278
multiple interactionsISORGD:685576480464CTD[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND1 mRNA, cyclopamine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND1 mRNA], cyclopamine inhibits the reaction [polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND1 mRNA]], polydatin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CCND1 mRNA]

PMID:27481074
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.