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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:138308
Term: kahweol
Definition: A diterpenoid with formula C20H26O3, isolated from the beans of Coffea arabica. It exhibits antioxidant, anti-inflammatory, anti-angiogenesis and anti-proliferative properties.
Chemical ID: MESH:C053401
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:685566480464CTDkahweol results in decreased expression of CCND1 protein

PMID:27424123, PMID:30205135
multiple interactionsISORGD:685566480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [kahweol results in decreased expression of CCND1 protein], 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [kahweol results in increased phosphorylation of CCND1 protein], benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [kahweol results in decreased expression of CCND1 protein], kahweol results in increased phosphorylation of and results in increased degradation of CCND1 protein, leptomycin B inhibits the reaction [kahweol results in increased degradation of CCND1 protein], Lithium Chloride inhibits the reaction [kahweol results in decreased expression of CCND1 protein], Lithium Chloride inhibits the reaction [kahweol results in increased phosphorylation of CCND1 protein], pyrazolanthrone inhibits the reaction [kahweol results in decreased expression of CCND1 protein], pyrazolanthrone inhibits the reaction [kahweol results in increased phosphorylation of CCND1 protein]

PMID:27424123
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.