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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68350
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr5a1
Name: nuclear receptor subfamily 5, group A, member 1
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDAtrazine results in decreased expression of NR5A1 mRNA

PMID:19541795
increases expressionEXP 6480464CTDAtrazine results in increased expression of NR5A1 mRNA

PMID:20667998
affects bindingISORGD:684936480464CTDAtrazine binds to NR5A1 protein

PMID:17520059
increases activityISORGD:684946480464CTDAtrazine results in increased activity of NR5A1 protein

PMID:18461179
increases expressionISORGD:684936480464CTDAtrazine results in increased expression of NR5A1 mRNA, Atrazine results in increased expression of NR5A1 protein

PMID:17520059, PMID:22378314
increases phosphorylationISORGD:684936480464CTDAtrazine results in increased phosphorylation of NR5A1 protein

PMID:18461179
multiple interactionsISORGD:684936480464CTDAtrazine binds to and results in increased activity of NR5A1 protein, Atrazine promotes the reaction [[NR5A1 protein binds to CYP19A1 gene] which results in increased expression of CYP19A1 mRNA], NR5A1 protein affects the reaction [Atrazine results in increased expression of CYP19A1 mRNA], NR5A1 protein affects the reaction [Atrazine results in increased expression of LHB mRNA], NR5A1 protein promotes the reaction [Atrazine results in increased expression of CYP11A1 mRNA], NR5A1 protein promotes the reaction [Atrazine results in increased expression of CYP19A1 mRNA], NR5A1 protein promotes the reaction [Atrazine results in increased expression of HSD11B2 mRNA], NR5A1 protein promotes the reaction [Atrazine results in increased expression of INHA mRNA], NR5A1 protein promotes the reaction [Atrazine results in increased expression of STAR mRNA]

PMID:17331471, PMID:17520059, PMID:18461179
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.