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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68346
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1a1
Name: aldo-keto reductase family 1 member A1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1a1increases expressionEXP 6480464CTDbisphenol A results in increased expression of AKR1A1 mRNAPMID:25181051 PMID:30816183 PMID:32528016
Akr1a1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of AKR1A1 genePMID:28505145
Akr1a1decreases expressionISOAKR1A1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of AKR1A1 proteinPMID:34186270
Akr1a1increases expressionISOAKR1A1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of AKR1A1 proteinPMID:37567409
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