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GENE - TERM ANNOTATION REPORT

RGD ID: 68321
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sec61a1
Name: SEC61 translocon subunit alpha 1
Acc ID: GO:0006616
Term: SRP-dependent cotranslational protein targeting to membrane, translocation
Definition: The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.
Definition Source(s): ISBN:0716731363
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sec61a1involved_inIBAPANTHER:PTN000097217 or SGD:S000004370 or UniProtKB:P0AGA21600115GO_CentralGO_REF:0000033

GO_REF:0000033
Sec61a1involved_inIEAPANTHER:PTHR10906:SF191600115TreeGrafterGO_REF:0000118

GO_REF:0000118
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