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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67383
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkcd
Name: protein kinase C, delta
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkcdincreases expressionEXP 6480464CTDParaquat results in increased expression of PRKCD mRNAPMID:18198484
Prkcdmultiple interactionsEXP 6480464CTDanacardic acid inhibits the reaction [Paraquat results in increased cleavage of and results in increased activity of PRKCD protein]; Butyrates promotes the reaction [Paraquat results in increased cleavage of and results in increased activity of PRKCD protein]; Paraquat results in increased cleavage of and results in increased activity of PRKCD protein; PRKCD mutant form inhibits the reaction [Paraquat results in increased expression of NOX1 mRNA]; PRKCD mutant form inhibits the reaction [Paraquat results in increased expression of NOX1 protein]PMID:21777615 PMID:23827392
Prkcddecreases expressionISOPrkcd (Mus musculus)6480464CTDParaquat results in decreased expression of PRKCD mRNAPMID:21371552
Prkcdmultiple interactionsISOPrkcd (Mus musculus)6480464CTD[APOD protein affects the susceptibility to Paraquat] which affects the expression of PRKCD mRNAPMID:21463325
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