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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67379
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acaa1a
Name: acetyl-CoA acyltransferase 1A
Acc ID: CHEBI:39421
Term: perfluorooctane-1-sulfonic acid
Definition: A perfluoroalkanesulfonic acid that is octane-1-sulfonic acid in which all seventeen of the hydrogens that are attached to carbons hvae been replaced by fluorines.
Chemical ID: MESH:C076994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acaa1aincreases expressionEXP 6480464CTDperfluorooctane sulfonic acid results in increased expression of ACAA1 mRNAPMID:16221955 PMID:18692542 PMID:19162173
Acaa1amultiple interactionsEXP 6480464CTD[perfluorooctane sulfonic acid results in increased activity of PPARA protein] which results in increased expression of ACAA1A mRNA; [perfluorooctane sulfonic acid results in increased activity of PPARA protein] which results in increased expression of ACAA1A proteinPMID:15071170
Acaa1aincreases expressionISOAcaa1a (Mus musculus)6480464CTDperfluorooctane sulfonic acid results in increased expression of ACAA1A mRNAPMID:19429403 PMID:20936131 PMID:21705711
Acaa1amultiple interactionsISOAcaa1a (Mus musculus)6480464CTD[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ACAA1A mRNA; [perfluorooctane sulfonic acid co-treated with Dietary Fats co-treated with Dietary Carbohydrates] results in increased expression of ACAA1A proteinPMID:32991729 PMID:36331819
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