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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631431
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Zhx3
Name: zinc fingers and homeoboxes 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Zhx3affects methylationISOZHX3 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of ZHX3 3' UTRPMID:27901495
Zhx3decreases expressionISOZHX3 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of ZHX3 mRNAPMID:20064835 PMID:26238291
Zhx3increases methylationISOZhx3 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of ZHX3 exonPMID:27901495
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