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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631377
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sp7
Name: Sp7 transcription factor
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sp7increases expressionEXP 6480464CTDcobaltous chloride results in increased expression of SP7 mRNAPMID:31472278
Sp7multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SP7 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SP7 protein]; iodopravadoline inhibits the reaction [cobaltous chloride results in increased expression of SP7 mRNA]; SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of SP7 mRNA]; SB 203580 inhibits the reaction [cobaltous chloride results in increased expression of SP7 protein]PMID:31472278
Sp7decreases expressionISOSp7 (Mus musculus)6480464CTDcobaltous chloride results in decreased expression of SP7 mRNAPMID:25966675
Sp7multiple interactionsISOSp7 (Mus musculus)6480464CTD[cobaltous chloride co-treated with chromic chloride] results in decreased expression of SP7 mRNAPMID:25966675
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