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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631344
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abca1
Name: ATP binding cassette subfamily A member 1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pleasant odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13323546480464CTDOzone results in decreased expression of ABCA1 mRNA

PMID:16183385
decreases expressionISORGD:7361576480464CTDOzone results in decreased expression of ABCA1 mRNA, Ozone results in decreased expression of ABCA1 protein

PMID:27703007
multiple interactionsISORGD:7361576480464CTDOzone inhibits the reaction [TO-901317 results in increased expression of ABCA1 mRNA]

PMID:27703007
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.