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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631335
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Obscn
Name: obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Obscnaffects methylationISOOBSCN (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of OBSCN exon; Benzo(a)pyrene affects the methylation of OBSCN intron; Benzo(a)pyrene affects the methylation of OBSCN promoterPMID:27901495 PMID:30157460
Obscndecreases methylationISOObscn (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of OBSCN exon; Benzo(a)pyrene results in decreased methylation of OBSCN intronPMID:27901495
Obscndecreases methylationISOOBSCN (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of OBSCN 3' UTRPMID:27901495
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