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GENE - TERM ANNOTATION REPORT

RGD ID: 628852
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cacna1b
Name: calcium voltage-gated channel subunit alpha1 B
Acc ID: GO:0007268
Term: chemical synaptic transmission
Definition: The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Definition Source(s): GOC:jl, MeSH:D009435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cacna1binvolved_inIBAFB:FBgn0263111 or MGI:109482 or MGI:88296 or PANTHER:PTN000004141 or Cacna1a (Rattus norvegicus) or ZFIN:ZDB-GENE-090514-31600115GO_CentralGO_REF:0000033

GO_REF:0000033
Cacna1binvolved_inIEAPANTHER:PTHR45628:SF61600115TreeGrafterGO_REF:0000118

GO_REF:0000118
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