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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628847
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk9
Name: mitogen-activated protein kinase 9
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk9decreases phosphorylationEXP 6480464CTDCurcumin results in decreased phosphorylation of MAPK9 proteinPMID:18332871
Mapk9multiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [sodium arsenite results in increased expression of MAPK9 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [Tetracaine results in increased phosphorylation of MAPK9 protein]; Curcumin results in decreased phosphorylation of and results in decreased activity of MAPK9 proteinPMID:11981161 PMID:17372590 PMID:24952339 PMID:27966075
Mapk9increases phosphorylationISOMAPK9 (Homo sapiens)6480464CTDCurcumin results in increased phosphorylation of MAPK9 proteinPMID:18316600
Mapk9multiple interactionsISOMapk9 (Mus musculus)6480464CTDCurcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK9 protein]; Curcumin inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein]PMID:18321868 PMID:34272803
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