Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
[[GW 4064 binds to and results in increased activity of NR1H4 protein] which binds to ABCB4 promoter] which results in increased expression of ABCB4 mRNA; [[GW 4064 results in increased activity of NR1H4 protein] which binds to FGF19 promoter] which results in increased expression of FGF19 mRNA; [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of SCARB1 mRNA; [GW 4064 co-treated with Oleic Acid] results in decreased expression of NR1H4 mRNA; [GW 4064 results in increased activity of NR1H4 protein] which binds to FGF19 promoter; [GW 4064 results in increased activity of NR1H4 protein] which results in increased expression of UGT1A3 mRNA; epigallocatechin gallate inhibits the reaction [GW 4064 results in increased activity of NR1H4 protein]; epigallocatechin gallate inhibits the reaction [GW 4064 results in increased expression of NR1H4 mRNA]; GW 4064 binds to and results in increased activity of NR1H4 protein; GW 4064 inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; GW 4064 inhibits the reaction [TNF protein results in increased expression of NR1H4 mRNA]; GW 4064 promotes the reaction [NCOA1 protein binds to NR1H4 protein]; GW 4064 promotes the reaction [NR1H4 protein binds to NCOA1 protein]; GW 4064 promotes the reaction [NR1H4 protein binds to SOD3 promoter]; GW 4064 promotes the reaction [NR1H4 protein results in increased export of Taurocholic Acid]; NR1H4 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]]; NR1H4 promotes the reaction [GW 4064 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]]
[GW 4064 binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in decreased expression of SLC10A1 mRNA; [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of NR0B2 mRNA; [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of SCARB1 mRNA; [GW 4064 binds to and results in increased activity of NR1H4 protein] which results in increased expression of SLC51B mRNA; [GW 4064 results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA; FGFR4 protein affects the reaction [[GW 4064 results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA]; GW 4064 binds to and results in increased activity of NR1H4 protein; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 mRNA]; GW 4064 inhibits the reaction [Oleanolic Acid results in decreased expression of NR1H4 protein]; GW 4064 promotes the reaction [NR1H4 protein binds to ACTG1 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to APOE gene]; GW 4064 promotes the reaction [NR1H4 protein binds to BCCIP gene]; GW 4064 promotes the reaction [NR1H4 protein binds to CAPRIN1 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to CDK5RAP2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to CEBPB gene]; GW 4064 promotes the reaction [NR1H4 protein binds to CKS2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to CNNM3 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to ELL2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to FCNA gene]; GW 4064 promotes the reaction [NR1H4 protein binds to FGA gene]; GW 4064 promotes the reaction [NR1H4 protein binds to FGF15 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to GATD1 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to GPBP1 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to GTF2A2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to HMGA1 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to IGFALS gene]; GW 4064 promotes the reaction [NR1H4 protein binds to IL17B gene]; GW 4064 promotes the reaction [NR1H4 protein binds to LDHA gene]; GW 4064 promotes the reaction [NR1H4 protein binds to MIR126 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to MIR499 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to NAT2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to NR0B2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to PCX gene]; GW 4064 promotes the reaction [NR1H4 protein binds to PDGFRB gene]; GW 4064 promotes the reaction [NR1H4 protein binds to PLAT gene]; GW 4064 promotes the reaction [NR1H4 protein binds to RARRES2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to SCARB1 intron]; GW 4064 promotes the reaction [NR1H4 protein binds to SLC10A1 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to SLC22A21 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to SLC25A3 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to SLC51A gene]; GW 4064 promotes the reaction [NR1H4 protein binds to SLC51B gene]; GW 4064 promotes the reaction [NR1H4 protein binds to SLC9A8 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to STAT2 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to SUMO3 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to TFAP2E gene]; GW 4064 promotes the reaction [NR1H4 protein binds to TLR3 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to TRPM7 gene]; GW 4064 promotes the reaction [NR1H4 protein binds to VKORC1 gene]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in decreased expression of FSHR mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in decreased expression of NR0B1 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in decreased expression of PDK4 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in decreased expression of STRA8 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in decreased expression of ZBTB16 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of ABCB11 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of ABCG5 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of APOA1 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of FABP6 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of FGF15 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of NR0B2 mRNA]; NR1H4 gene mutant form inhibits the reaction [GW 4064 results in increased expression of SOD3 mRNA]; NR1H4 mutant form inhibits the reaction [GW 4064 results in increased expression of HHEX mRNA]; NR1H4 mutant form inhibits the reaction [GW 4064 results in increased expression of NR0B2 mRNA]; NR1H4 protein promotes the reaction [GW 4064 results in increased expression of ABCB11 protein]; systhane inhibits the reaction [GW 4064 results in increased activity of NR1H4 protein]
