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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628831
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Acc ID: CHEBI:47898
Term: 4'-epidoxorubicin
Definition: An anthracycline that is the 4'-epi-isomer of doxorubicin.
Chemical ID: MESH:D015251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h4multiple interactionsISONR1H4 (Homo sapiens)6480464CTDEpirubicin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NR1H4 protein affects the localization of NCOA2 protein]]; Epirubicin inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Epirubicin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]PMID:25257666
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