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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628825
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Enpp1
Name: ectonucleotide pyrophosphatase/phosphodiesterase 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Enpp1increases expressionEXP 6480464CTDbisphenol A results in increased expression of ENPP1 mRNAPMID:25181051
Enpp1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of ENPP1 mRNA; [bisphenol A co-treated with Estradiol] results in increased expression of ENPP1 mRNAPMID:26496021 PMID:36041667
Enpp1affects expressionISOENPP1 (Homo sapiens)6480464CTDbisphenol A affects the expression of ENPP1 mRNAPMID:30903817
Enpp1decreases expressionISOENPP1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of ENPP1 mRNA; bisphenol A results in decreased expression of ENPP1 proteinPMID:29275510 PMID:31675489
Enpp1decreases expressionISOEnpp1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of ENPP1 mRNAPMID:20739668
Enpp1increases expressionISOEnpp1 (Mus musculus)6480464CTDbisphenol A results in increased expression of ENPP1 mRNAPMID:30951980 PMID:33221593 PMID:34585602
Enpp1multiple interactionsISOENPP1 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ENPP1 mRNAPMID:28628672
Enpp1multiple interactionsISOEnpp1 (Mus musculus)6480464CTD[bisphenol A co-treated with Tretinoin] results in decreased expression of ENPP1 mRNAPMID:30951980
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