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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628734
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfsf10
Name: TNF superfamily member 10
Acc ID: CHEBI:75408
Term: sulindac sulfide
Definition: An aryl sulfide that is a metabolite of sulindac. A non-steroidal anti-inflammatory drug, which also has anticancer activity.
Chemical ID: MESH:C025462
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfsf10multiple interactionsISOTNFSF10 (Homo sapiens)6480464CTDBAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]]; BAX protein affects the reaction [TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP8 protein]; TNFSF10 protein promotes the reaction [sulindac sulfide results in increased cleavage of and results in increased activity of CASP9 protein]PMID:12203115
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