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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628734
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfsf10
Name: TNF superfamily member 10
Acc ID: CHEBI:4305
Term: dacarbazine
Definition: A monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma.
Chemical ID: MESH:D003606
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfsf10multiple interactionsISOTNFSF10 (Homo sapiens)6480464CTDTNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP3 protein]; TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein]PMID:17410615
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