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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628714
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd86
Name: CD86 molecule
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd86affects expressionISOCD86 (Homo sapiens)6480464CTDEstradiol affects the expression of CD86 mRNAPMID:22574217
Cd86increases expressionISOCd86 (Mus musculus)6480464CTDEstradiol results in increased expression of CD86 proteinPMID:28811679
Cd86multiple interactionsISOCD86 (Homo sapiens)6480464CTD[Lipopolysaccharides co-treated with Estradiol] results in increased expression of CD86 proteinPMID:32328699
Cd86multiple interactionsISOCd86 (Mus musculus)6480464CTD[Estradiol results in increased susceptibility to CpG ODN 1826] which results in increased expression of CD86 protein; Estradiol inhibits the reaction [[CSF2 protein co-treated with IL4 protein] results in increased expression of CD86 protein]; Estradiol promotes the reaction [Lipopolysaccharides results in increased expression of CD86 protein]PMID:21538406 PMID:28811679
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