Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628627
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2b3
Name: cytochrome P450, family 2, subfamily b, polypeptide 3
Acc ID: CHEBI:44409
Term: NADP zwitterion
Definition: A NADP that has formula 743.40528.
Chemical ID: MESH:D009249
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b3multiple interactionsISOCYP2B6 (Homo sapiens)6480464CTD[CYP2B6 protein co-treated with cupric chloride co-treated with NADP] results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone; [CYP2B6 protein co-treated with cupric chloride co-treated with NADP] results in increased metabolism of N'-nitrosonornicotine; [Ethinyl Estradiol co-treated with NADP] results in decreased activity of CYP2B6 protein; [isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein; Mephenytoin inhibits the reaction [[isoimperatorin co-treated with NADP] results in decreased activity of CYP2B6 protein]PMID:11805216 PMID:16485904 PMID:25500267 PMID:32672941
Go Back to source page   Continue to Ontology report