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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628626
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp3a23-3a1
Name: cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
Acc ID: CHEBI:34648
Term: clofibric acid
Definition: A monocarboxylic acid that is isobutyric acid substituted at position 2 by a p-chlorophenoxy group. It is a metabolite of the drug clofibrate.
Chemical ID: MESH:D002995
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp3a23-3a1increases expressionEXP 6480464CTDClofibric Acid results in increased expression of CYP3A23-3A1 mRNAPMID:15788368
Cyp3a23-3a1multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of CYP3A23-3A1 mRNA; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased activity of CYP3A23-3A1 protein]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 mRNA]; [sudan III binds to AHR protein] inhibits the reaction [[Clofibric Acid binds to PPARA protein] which results in increased expression of CYP3A23-3A1 protein]; Clofibric Acid results in increased expression of and results in increased activity of CYP3A23-3A1 proteinPMID:15788368 PMID:17602206
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