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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628622
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Alk
Name: ALK receptor tyrosine kinase
Acc ID: CHEBI:23995
Term: N-ethyl-N-nitrosourea
Definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.
Chemical ID: MESH:D005038
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Alkincreases mutagenesisISOALK (Homo sapiens)6480464CTDEthylnitrosourea results in increased mutagenesis of ALK proteinPMID:21948233 PMID:22034911
Alkmultiple interactionsISOALK (Homo sapiens)6480464CTD[Ethylnitrosourea results in increased mutagenesis of ALK protein] inhibits the reaction [crizotinib results in decreased phosphorylation of ALK protein]; [Ethylnitrosourea results in increased mutagenesis of ALK protein] which results in decreased susceptibility to crizotinib; [Ethylnitrosourea results in increased mutagenesis of ALK protein] which results in decreased susceptibility to NVP-TAE684PMID:22034911
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