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GENE - TERM ANNOTATION REPORT

RGD ID: 628593
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Unc13d
Name: unc-13 homolog D
Acc ID: GO:0002432
Term: granuloma formation
Definition: The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic.
Definition Source(s): GO_REF:0000022, GOC:add, ISBN:068340007X, ISBN:0721601464, ISBN:081533642X
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Unc13dacts_upstream_of_or_withinISOUnc13d (Mus musculus)1624291RGDMGI:3628822 PMID:17420270

PMID:17420270
Unc13dinvolved_inIEAUniProtKB:B2RUP2 or ensembl:ENSMUSP000001020581600115EnsemblGO_REF:0000107

GO_REF:0000107
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