Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDStreptozocin results in increased expression of DDIT3, Streptozocin results in increased expression of DDIT3 mRNA, Streptozocin results in increased expression of DDIT3 protein

PMID:23499715, PMID:24967692, PMID:29935216
multiple interactionsEXP 6480464CTD[Streptozocin co-treated with bisphenol A] results in increased expression of DDIT3 protein, [Streptozocin co-treated with Ethinyl Estradiol] results in increased expression of DDIT3 mRNA, [Streptozocin co-treated with Ethinyl Estradiol] results in increased expression of DDIT3 protein, [Streptozocin co-treated with octylphenol] results in increased expression of DDIT3 mRNA, [Streptozocin co-treated with octylphenol] results in increased expression of DDIT3 protein, FGF21 protein affects the reaction [Streptozocin results in increased expression of DDIT3], Streptozocin promotes the reaction [bisphenol A results in increased expression of DDIT3 mRNA], sulforafan inhibits the reaction [Streptozocin results in increased expression of DDIT3 protein]

PMID:23499715, PMID:24967692, PMID:29935216
increases expressionISORGD:623916480464CTDStreptozocin results in increased expression of DDIT3 protein

PMID:30980806
multiple interactionsISORGD:623916480464CTD4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of DDIT3 protein]

PMID:30980806
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.