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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:691656480464CTDochratoxin A metabolite results in decreased expression of DDIT3 mRNA, ochratoxin A results in decreased expression of DDIT3 mRNA

PMID:24356939, PMID:30559759, PMID:30763683
decreases methylationISORGD:691656480464CTDochratoxin A results in decreased methylation of DDIT3 promoter

PMID:30559759
increases expressionISORGD:623916480464CTDochratoxin A results in increased expression of DDIT3 mRNA

PMID:12700408
increases expressionISORGD:691656480464CTDochratoxin A results in increased expression of DDIT3 mRNA

PMID:30008028
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.