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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:77012
Term: methylseleninic acid
Definition: An organoselenium compound that is seleninic acid in which the hydrogen attached to selenium is replaced by a methyl group.
Chemical ID: MESH:C008493
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:691656480464CTDmethylselenic acid results in increased expression of DDIT3 mRNA, methylselenic acid results in increased expression of DDIT3 protein

PMID:11830524, PMID:12517777, PMID:16204082, PMID:16205645, PMID:19276161, PMID:28161410
multiple interactionsISORGD:691656480464CTDDDIT3 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A mRNA], DDIT3 protein affects the reaction [methylselenic acid results in increased expression of CDKN1A protein], HSPA5 protein inhibits the reaction [methylselenic acid results in increased expression of DDIT3 protein]

PMID:16204082, PMID:16205645
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.