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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDMethamphetamine results in increased expression of DDIT3 protein

PMID:27323860
increases expressionISORGD:623916480464CTDMethamphetamine results in increased expression of DDIT3 mRNA, Methamphetamine results in increased expression of DDIT3 protein

PMID:15644446, PMID:19564919, PMID:28070110, PMID:28619521
increases expressionISORGD:691656480464CTDMethamphetamine results in increased expression of DDIT3 mRNA, Methamphetamine results in increased expression of DDIT3 protein

PMID:27323860
multiple interactionsISORGD:623916480464CTD[Methamphetamine co-treated with SCH 23390] results in increased expression of DDIT3 mRNA, Melatonin inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein], SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]

PMID:19564919, PMID:28070110
multiple interactionsISORGD:691656480464CTDATF4 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA], ATF4 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein], ATF6 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA], ATF6 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein], DDIT3 protein affects the reaction [Methamphetamine results in increased cleavage of CASP3 protein], DDIT3 protein affects the reaction [Methamphetamine results in increased cleavage of CASP9 protein], EIF2AK3 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA], EIF2AK3 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein], ERN1 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA], ERN1 protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein], Naltrexone inhibits the reaction [Methamphetamine results in increased expression of DDIT3 mRNA], Naltrexone inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein], norbinaltorphimine inhibits the reaction [Methamphetamine results in increased expression of DDIT3 mRNA], norbinaltorphimine inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein], RELA protein affects the reaction [Methamphetamine results in increased expression of DDIT3 mRNA], RELA protein affects the reaction [Methamphetamine results in increased expression of DDIT3 protein]

PMID:27323860
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.