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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:52717
Term: bortezomib
Definition: L-Phenylalaninamide substituted at the amide nitrogen by a 1-(dihydroxyboranyl)-3-methylbutyl group and at N(alpha) by a pyrazin-2-ylcarbonyl group. It is a dipeptidyl boronic acid that reversibly inhibits the 26S proteasome.
Chemical ID: MESH:D000069286
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDBortezomib results in increased expression of DDIT3 mRNA, Bortezomib results in increased expression of DDIT3 protein

PMID:15509775
multiple interactionsEXP 6480464CTD1, 2-Dihydroxybenzene-3, 5-Disulfonic Acid Disodium Salt inhibits the reaction [Bortezomib results in increased expression of DDIT3 protein], Bortezomib inhibits the reaction [1, 2-dithiol-3-thione inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA]]

PMID:15509775, PMID:22959925
decreases response to substanceISORGD:691656480464CTDDDIT3 results in decreased susceptibility to Bortezomib

PMID:20022965
increases expressionISORGD:623916480464CTDBortezomib results in increased expression of DDIT3 protein

PMID:20830808
increases expressionISORGD:691656480464CTDBortezomib results in increased expression of DDIT3 mRNA, Bortezomib results in increased expression of DDIT3 protein

PMID:16024631, PMID:16357177, PMID:17659339, PMID:17709599, PMID:17898295, PMID:18723477, PMID:20110775, PMID:24291039
multiple interactionsISORGD:691656480464CTDBortezomib inhibits the reaction [Tunicamycin results in increased expression of DDIT3 protein], Bortezomib promotes the reaction [gambogic acid results in increased expression of DDIT3 protein], gambogic acid promotes the reaction [Bortezomib results in increased expression of DDIT3 protein]

PMID:16357177, PMID:24291039
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.