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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDIndomethacin results in increased expression of DDIT3 mRNA

PMID:18799549
increases expressionISORGD:623916480464CTDIndomethacin results in increased expression of DDIT3 mRNA

PMID:16184411, PMID:18799549
increases expressionISORGD:691656480464CTDIndomethacin results in increased expression of DDIT3 protein

PMID:17341418, PMID:27358234
multiple interactionsISORGD:691656480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of DDIT3 mRNA, pyrazolanthrone inhibits the reaction [Indomethacin results in increased expression of DDIT3 protein], SB 203580 inhibits the reaction [Indomethacin results in increased expression of DDIT3 protein], U 0126 inhibits the reaction [Indomethacin results in increased expression of DDIT3 protein]

PMID:17341418, PMID:28628672
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.