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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:47381
Term: diclofenac
Definition: A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Chemical ID: MESH:D004008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDiclofenac results in increased expression of DDIT3 protein

PMID:20668000
increases response to substanceEXP 6480464CTDDDIT3 results in increased susceptibility to Diclofenac

PMID:20668000
increases expressionISORGD:623916480464CTDDiclofenac results in increased expression of DDIT3 mRNA

PMID:18172885
increases expressionISORGD:691656480464CTDDiclofenac results in increased expression of DDIT3 mRNA, Diclofenac results in increased expression of DDIT3 protein

PMID:24752500, PMID:27313093, PMID:27358234
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.