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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:46936
Term: nonivamide
Definition: A capsaicinoid that is the carboxamide resulting from the formal condensation of the amino group of 4-hydroxy-3-methoxybenzylamine with the carboxy group of nonanoic acid. It is the active ingredient in many pepper sprays.
Chemical ID: MESH:C040937
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDnonivamide affects the expression of DDIT3 mRNA

PMID:21949157
decreases response to substanceISORGD:691656480464CTDDDIT3 protein results in decreased susceptibility to nonivamide

PMID:17332266
increases expressionISORGD:691656480464CTDnonivamide results in increased expression of DDIT3 mRNA, nonivamide results in increased expression of DDIT3 protein

PMID:17332266, PMID:21343315, PMID:21949157
multiple interactionsISORGD:691656480464CTD[nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of DDIT3 mRNA

PMID:17332266
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.