RGD Gene Chemical Interaction Report

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	62396
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Ddit3
Name:	DNA-damage inducible transcript 3

Acc ID:	CHEBI:46936
Term:	nonivamide
Definition:	A capsaicinoid that is the carboxamide resulting from the formal condensation of the amino group of 4-hydroxy-3-methoxybenzylamine with the carboxy group of nonanoic acid. It is the active ingredient in many pepper sprays.
Chemical ID:	MESH:C040937

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	EXP		6480464	CTD	nonivamide affects the expression of DDIT3 mRNA	PMID:21949157
decreases response to substance	ISO	RGD:69165	6480464	CTD	DDIT3 protein results in decreased susceptibility to nonivamide	PMID:17332266
increases expression	ISO	RGD:69165	6480464	CTD	nonivamide results in increased expression of DDIT3 mRNA, nonivamide results in increased expression of DDIT3 protein	PMID:17332266, PMID:21343315, PMID:21949157
multiple interactions	ISO	RGD:69165	6480464	CTD	[nonivamide binds to and results in increased activity of TRPV1 protein] which results in increased expression of DDIT3 mRNA	PMID:17332266

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

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