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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCyclosporine results in increased expression of DDIT3 mRNA

PMID:19770486, PMID:23958496, PMID:25224403, PMID:27585667
increases phosphorylationEXP 6480464CTDCyclosporine results in increased phosphorylation of DDIT3 protein

PMID:23958496
multiple interactionsEXP 6480464CTDethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of DDIT3 mRNA], salubrinal promotes the reaction [Cyclosporine results in increased expression of DDIT3 protein], TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of DDIT3 mRNA]

PMID:23958496, PMID:27585667
affects expressionISORGD:691656480464CTDCyclosporine affects the expression of DDIT3 mRNA

PMID:25224403
increases expressionISORGD:623916480464CTDCyclosporine results in increased expression of DDIT3 mRNA

PMID:25596134
increases expressionISORGD:691656480464CTDCyclosporine results in increased expression of DDIT3 mRNA

PMID:19159671, PMID:20106945, PMID:21632981, PMID:22147139, PMID:24973091, PMID:25562108, PMID:25596134, PMID:27989131, PMID:30008028
multiple interactionsISORGD:691656480464CTD[Cyclosporine co-treated with Cholic Acids] affects the expression of DDIT3 mRNA

PMID:27344345
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.