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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:28714
Term: S-butyl-DL-homocysteine (S,R)-sulfoximine
Definition: A sulfoximide that is the sulfoximine derivative of an analogue of DL-methionine in which the S-methyl group is replaced by S-butyl.
Chemical ID: MESH:D019328
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:691656480464CTDButhionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 mRNA], Buthionine Sulfoximine promotes the reaction [Curcumin results in increased expression of DDIT3 protein], Buthionine Sulfoximine promotes the reaction [pterostilbene results in increased expression of DDIT3 protein]

PMID:17171638, PMID:25341683
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.