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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ddit3increases expressionEXP 6480464CTDRotenone results in increased expression of DDIT3 mRNA; Rotenone results in increased expression of DDIT3 proteinPMID:19304788 PMID:22016648 PMID:23186747 PMID:25428620 PMID:32033040 PMID:32189544
Ddit3multiple interactionsEXP 6480464CTD[Bilirubin co-treated with Rotenone] promotes the reaction [Cannabidiol results in increased expression of DDIT3 mRNA]; DDIT3 protein affects the reaction [Rotenone results in increased expression of ATF3 mRNA]; DDIT3 protein affects the reaction [Rotenone results in increased expression of GSTA1 mRNA]; DDIT3 protein affects the reaction [Rotenone results in increased expression of TRIB3 mRNA]; Metformin inhibits the reaction [Rotenone results in increased expression of DDIT3 mRNA]; Rotenone promotes the reaction [Cannabidiol results in increased expression of DDIT3 mRNA]; salubrinal inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]PMID:19304788 PMID:25428620 PMID:32033040 PMID:32189544
Ddit3increases expressionISODdit3 (Rattus norvegicus)6480464CTDRotenone results in increased expression of DDIT3 mRNA; Rotenone results in increased expression of DDIT3 proteinPMID:12486162 PMID:26446018 PMID:27016191 PMID:27252111 PMID:31969611 PMID:33137417 PMID:35544339 PMID:35654124 PMID:36538285 PMID:37105514
Ddit3increases expressionISODDIT3 (Homo sapiens)6480464CTDRotenone results in increased expression of DDIT3 mRNA; Rotenone results in increased expression of DDIT3 proteinPMID:19233273 PMID:26864693 PMID:28940366 PMID:30141137 PMID:36586010
Ddit3multiple interactionsISODdit3 (Rattus norvegicus)6480464CTD7-methyl-5-(1-((3-(trifluoromethyl)phenyl)acetyl)-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo(2,3-d)pyrimidin-4-amine inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]; ADIPOQ protein inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]; dorsomorphin inhibits the reaction [ADIPOQ protein inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]]; dorsomorphin promotes the reaction [Rotenone results in increased expression of DDIT3 protein]; empagliflozin inhibits the reaction [Rotenone results in increased expression of DDIT3 mRNA]; Quercetin inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]; repaglinide inhibits the reaction [Rotenone results in increased expression of DDIT3 mRNA]; Resveratrol inhibits the reaction [Rotenone results in increased expression of DDIT3 mRNA]; Roflumilast inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]PMID:26446018 PMID:27016191 PMID:27252111 PMID:33137417 PMID:35654124 PMID:36538285 PMID:37105514
Ddit3multiple interactionsISODDIT3 (Homo sapiens)6480464CTDgeraniol inhibits the reaction [Rotenone results in increased expression of DDIT3 protein]; MIR384 mRNA promotes the reaction [Rotenone results in increased expression of DDIT3 protein]PMID:26864693 PMID:30141137
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