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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ddit3decreases expressionEXP 6480464CTDFolic Acid results in decreased expression of DDIT3 mRNAPMID:25629700
Ddit3multiple interactionsEXP 6480464CTD[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of DDIT3 mRNA; [Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of DDIT3 protein; [Vitamin B 6 co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of DDIT3 protein]PMID:22206623 PMID:23439872 PMID:37263574
Ddit3multiple interactionsISODdit3 (Rattus norvegicus)6480464CTD[Folic Acid deficiency co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of DDIT3 mRNAPMID:19566968
Ddit3multiple interactionsISODDIT3 (Homo sapiens)6480464CTD[Folic Acid co-treated with Methyl Methanesulfonate] results in increased expression of DDIT3 mRNA; [Folic Acid deficiency co-treated with Methotrexate] results in increased expression of DDIT3 mRNA; [Vitamin B 6 co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of DDIT3 protein]; Folic Acid inhibits the reaction [Camptothecin results in decreased expression of DDIT3 mRNA]; Folic Acid inhibits the reaction [Doxorubicin results in decreased expression of DDIT3 mRNA]PMID:24657277 PMID:30581319 PMID:37263574
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