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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceEXP 6480464CTDDDIT3 gene mutant form results in decreased susceptibility to Amiodarone

PMID:28962527
multiple interactionsEXP 6480464CTD1-(3, 4-dihydroxyphenyl)-2-thiocyanate-ethanone inhibits the reaction [Amiodarone results in increased expression of DDIT3 mRNA], Amiodarone results in increased expression of and affects the localization of DDIT3 protein, DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased expression of CIDEA mRNA], DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased expression of CIDEC mRNA], DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased expression of CIDEC protein], DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased expression of DNAJB9 mRNA], DDIT3 gene mutant form inhibits the reaction [Amiodarone results in increased splicing of XBP1 mRNA]

PMID:28962527
increases expressionISORGD:691656480464CTD[Amiodarone results in increased expression of DDIT3 mRNA] which results in increased expression of TNFRSF10B mRNA, [Amiodarone results in increased expression of DDIT3 protein] which results in increased expression of TNFRSF10B protein, Amiodarone results in increased expression of DDIT3 mRNA, Amiodarone results in increased expression of DDIT3 protein

PMID:19774075, PMID:21292685
multiple interactionsISORGD:691656480464CTDDDIT3 mutant form inhibits the reaction [Amiodarone results in increased expression of TNFRSF10B], Egtazic Acid inhibits the reaction [Amiodarone results in increased expression of DDIT3]

PMID:21292685
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.