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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDNicotine inhibits the reaction [1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine results in increased expression of DDIT3 protein]

PMID:28082123
multiple interactionsISORGD:623916480464CTDNicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of DDIT3 protein]

PMID:28082123
multiple interactionsISORGD:691656480464CTDNicotine inhibits the reaction [Cisplatin results in increased expression of DDIT3 mRNA]

PMID:11592233
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.