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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62391
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ddit3increases expressionEXP 6480464CTDAcetaminophen results in increased expression of DDIT3 mRNAPMID:12883083 PMID:17202762 PMID:17522070 PMID:18246545 PMID:33387578
Ddit3affects expressionISODdit3 (Mus musculus)6480464CTDAcetaminophen affects the expression of DDIT3 mRNAPMID:15606129 PMID:17562736
Ddit3affects localizationISODdit3 (Mus musculus)6480464CTDAcetaminophen affects the localization of DDIT3 proteinPMID:14747384
Ddit3increases expressionISODdit3 (Mus musculus)6480464CTDAcetaminophen results in increased expression of DDIT3 mRNA; Acetaminophen results in increased expression of DDIT3 proteinPMID:11264010 PMID:12540782 PMID:12958197 PMID:14747384 PMID:18544908 PMID:19931551 PMID:25265579 PMID:25743375 PMID:31524377 PMID:38042273
Ddit3increases expressionISODDIT3 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of DDIT3 mRNAPMID:21420995 PMID:29067470 PMID:30008028
Ddit3multiple interactionsISODdit3 (Mus musculus)6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of DDIT3 mRNA; acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Acetaminophen results in increased expression of DDIT3 protein]; Fomepizole inhibits the reaction [Acetaminophen results in increased expression of DDIT3 protein]; Guanabenz inhibits the reaction [Acetaminophen results in increased expression of DDIT3 protein]; O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of DDIT3 mRNA]; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DDIT3 mRNA]; saikosaponin D inhibits the reaction [Acetaminophen results in increased expression of DDIT3 mRNA]; YAP1 gene mutant form promotes the reaction [Acetaminophen results in increased expression of DDIT3 mRNA]PMID:12540782 PMID:17585979 PMID:25265579 PMID:31524377 PMID:34546377 PMID:38042273
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