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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62391
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ddit3increases expressionEXP 6480464CTDCyclosporine results in increased expression of DDIT3 mRNAPMID:25596134 PMID:35033536
Ddit3affects expressionISODDIT3 (Homo sapiens)6480464CTDCyclosporine affects the expression of DDIT3 mRNAPMID:25224403
Ddit3increases expressionISODdit3 (Mus musculus)6480464CTDCyclosporine results in increased expression of DDIT3 mRNAPMID:19770486 PMID:23958496 PMID:25224403 PMID:27585667
Ddit3increases expressionISODDIT3 (Homo sapiens)6480464CTDCyclosporine results in increased expression of DDIT3 mRNAPMID:19159671 PMID:20106945 PMID:21632981 PMID:22147139 PMID:24973091 PMID:25562108 PMID:25596134 PMID:27989131 PMID:30008028 PMID:32152650 PMID:33631201 PMID:34681664 PMID:35033536
Ddit3increases phosphorylationISODdit3 (Mus musculus)6480464CTDCyclosporine results in increased phosphorylation of DDIT3 proteinPMID:23958496
Ddit3multiple interactionsISODdit3 (Mus musculus)6480464CTDethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Cyclosporine results in increased expression of DDIT3 mRNA]; salubrinal promotes the reaction [Cyclosporine results in increased expression of DDIT3 protein]; TLR4 gene mutant form inhibits the reaction [Cyclosporine results in increased expression of DDIT3 mRNA]PMID:23958496 PMID:27585667
Ddit3multiple interactionsISODDIT3 (Homo sapiens)6480464CTD4-phenylbutyric acid inhibits the reaction [Cyclosporine results in increased expression of and affects the localization of DDIT3 protein]; [Cyclosporine co-treated with Cholic Acids] affects the expression of DDIT3 mRNA; [Cyclosporine co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of DDIT3 mRNA; Cyclosporine results in increased expression of and affects the localization of DDIT3 protein; EIF2AK3 protein affects the reaction [Cyclosporine results in increased expression of DDIT3 protein]; ursodoxicoltaurine inhibits the reaction [Cyclosporine results in increased expression of and affects the localization of DDIT3 protein]PMID:27344345 PMID:32152650 PMID:35033536
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