GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Pdx1 | decreases expression | EXP | | 6480464 | CTD | bisphenol A results in decreased expression of PDX1 mRNA | PMID:22946080 PMID:25181051 PMID:32701268 | Pdx1 | decreases methylation | EXP | | 6480464 | CTD | bisphenol A results in decreased methylation of PDX1 gene | PMID:32701268 | Pdx1 | multiple interactions | EXP | | 6480464 | CTD | [bisphenol A co-treated with tributyltin] results in decreased expression of PDX1 mRNA | PMID:31129395 | Pdx1 | increases expression | ISO | Pdx1 (Mus musculus) | 6480464 | CTD | bisphenol A results in increased expression of PDX1 mRNA; bisphenol A results in increased expression of PDX1 protein | PMID:27623287 PMID:28774890 PMID:29161229 PMID:35457000 | Pdx1 | multiple interactions | ISO | PDX1 (Homo sapiens) | 6480464 | CTD | [bisphenol A co-treated with Fulvestrant] results in increased methylation of PDX1 gene | PMID:31601247 | Pdx1 | multiple interactions | ISO | Pdx1 (Mus musculus) | 6480464 | CTD | GPER1 protein affects the reaction [bisphenol A results in increased expression of PDX1 mRNA]; PDX1 protein affects the reaction [bisphenol A promotes the reaction [Glucose results in increased secretion of INS protein]] | PMID:28774890 | |
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