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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62287
Species: Mus musculus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:35176
Term: zinc sulfate
Definition: A metal sulfate compound having zinc(2+) as the counterion.
Chemical ID: MESH:D019287
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptendecreases expressionEXP 6480464CTDZinc Sulfate results in decreased expression of PTEN proteinPMID:20100827
Ptenincreases response to substanceISOPten (Rattus norvegicus)6480464CTDPTEN protein results in increased susceptibility to Zinc SulfatePMID:20100827
Ptenincreases ubiquitinationISOPten (Rattus norvegicus)6480464CTDZinc Sulfate results in increased ubiquitination of PTEN proteinPMID:20100827
Ptenmultiple interactionsISOPten (Rattus norvegicus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Zinc Sulfate results in decreased stability of PTEN protein]; Wortmannin inhibits the reaction [Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]]; Wortmannin inhibits the reaction [Zinc Sulfate results in decreased expression of PTEN protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased ubiquitination of PTEN protein]; Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]; Zinc Sulfate results in decreased expression of and results in decreased stability of PTEN proteinPMID:20100827
Ptenmultiple interactionsISOPTEN (Homo sapiens)6480464CTDPTEN mutant form inhibits the reaction [Zinc Sulfate results in increased expression of SLC30A1 mRNA]; PTEN promotes the reaction [Zinc Sulfate results in increased expression of MT2A mRNA]PMID:21883094
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