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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62287
Species: Mus musculus
RGD Object: Gene
Symbol: Pten
Name: phosphatase and tensin homolog
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptendecreases methylationISOPTEN (Homo sapiens)6480464CTDTretinoin results in decreased methylation of PTEN promoterPMID:21801466
Ptenincreases expressionISOPTEN (Homo sapiens)6480464CTDTretinoin results in increased expression of PTEN mRNAPMID:23724009 PMID:33167477
Ptenmultiple interactionsISOPTEN (Homo sapiens)6480464CTD[Tretinoin co-treated with IFNG protein] results in increased expression of PTEN protein; decitabine promotes the reaction [Tretinoin results in decreased methylation of PTEN promoter]; fludarabine promotes the reaction [Tretinoin results in decreased methylation of PTEN promoter]; Tretinoin promotes the reaction [decitabine results in decreased methylation of PTEN promoter]PMID:17960384 PMID:21801466
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