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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62258
Species: Mus musculus
RGD Object: Gene
Symbol: Ptpn1
Name: protein tyrosine phosphatase, non-receptor type 1
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptpn1increases response to substanceEXP 6480464CTDPTPN1 gene mutant form results in increased susceptibility to TunicamycinPMID:22509299
Ptpn1multiple interactionsEXP 6480464CTDPTPN1 gene mutant form promotes the reaction [Tunicamycin results in increased activity of and results in increased phosphorylation of EIF2AK3 protein]; PTPN1 gene mutant form promotes the reaction [Tunicamycin results in increased activity of and results in increased phosphorylation of EIF2S1 protein]; PTPN1 gene mutant form promotes the reaction [Tunicamycin results in increased expression of DDIT3 protein]; PTPN1 gene mutant form promotes the reaction [Tunicamycin results in increased expression of HSPA5 protein]; Tunicamycin promotes the reaction [PTPN1 protein binds to EIF2AK3 protein]; Tunicamycin promotes the reaction [PTPN1 protein binds to ERN1 protein]; Tunicamycin promotes the reaction [PTPN1 protein binds to HSPA5 protein]PMID:22509299 PMID:29894845
Ptpn1decreases expressionISOPTPN1 (Homo sapiens)6480464CTDTunicamycin results in decreased expression of PTPN1 mRNAPMID:29453283
Ptpn1multiple interactionsISOPTPN1 (Homo sapiens)6480464CTDPTPN1 protein affects the reaction [Tunicamycin results in increased phosphorylation of EIF2S1 protein]PMID:28359145
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