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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62252
Species: Mus musculus
RGD Object: Gene
Symbol: Txnrd1
Name: thioredoxin reductase 1
Acc ID: CHEBI:31823
Term: mercury dichloride
Definition: A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.
Chemical ID: MESH:D008627
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Txnrd1decreases activityISOTxnrd1 (Rattus norvegicus)6480464CTDMercuric Chloride results in decreased activity of TXNRD1 proteinPMID:18321861 PMID:20810785
Txnrd1decreases activityISOTXNRD1 (Homo sapiens)6480464CTDMercuric Chloride results in decreased activity of TXNRD1 proteinPMID:17959236 PMID:20810785
Txnrd1increases expressionISOTxnrd1 (Rattus norvegicus)6480464CTDMercuric Chloride results in increased expression of TXNRD1 mRNAPMID:16507785
Txnrd1increases expressionISOTXNRD1 (Homo sapiens)6480464CTDMercuric Chloride results in increased expression of TXNRD1 mRNA; Mercuric Chloride results in increased expression of TXNRD1 proteinPMID:24816296
Txnrd1multiple interactionsISOTxnrd1 (Rattus norvegicus)6480464CTD[Sodium Selenite co-treated with NADP] inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]; Dimercaprol inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]; dimethyl mercaptosuccinate inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]; Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]; Unithiol inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]PMID:20810785
Txnrd1multiple interactionsISOTXNRD1 (Homo sapiens)6480464CTDMercuric Chloride promotes the reaction [Sodium Selenite results in increased expression of TXNRD1 mRNA]; Sodium Selenite inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]; Sodium Selenite promotes the reaction [Mercuric Chloride results in increased expression of TXNRD1 mRNA]; Sodium Selenite promotes the reaction [Mercuric Chloride results in increased expression of TXNRD1 protein]PMID:20810785 PMID:24816296
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