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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62221
Species: Mus musculus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Acc ID: CHEBI:77986
Term: dibenziodolium
Definition: An organic cation that is fluorene in which the methylene group is replaced by a positively charged iodine.
Chemical ID: MESH:C007517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1adecreases expressionISOHIF1A (Homo sapiens)6480464CTDdiphenyleneiodonium results in decreased expression of HIF1A proteinPMID:23144690
Hif1aincreases expressionISOHif1a (Rattus norvegicus)6480464CTDdiphenyleneiodonium results in increased expression of HIF1A proteinPMID:12595275
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTDdiphenyleneiodonium inhibits the reaction [[[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA]; diphenyleneiodonium inhibits the reaction [[Arsenic results in increased abundance of Reactive Oxygen Species] which results in increased expression of HIF1A protein]; diphenyleneiodonium inhibits the reaction [Cadmium Chloride results in increased expression of HIF1A protein]PMID:21687637 PMID:21984483
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