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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62221
Species: Mus musculus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Acc ID: CHEBI:49553
Term: copper(II) chloride
Definition: An inorganic chloride of copper in which the metal is in the +2 oxidation state.
Chemical ID: MESH:C029892
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1aaffects localizationISOHIF1A (Homo sapiens)6480464CTDcupric chloride affects the localization of HIF1A proteinPMID:15741220
Hif1adecreases hydroxylationISOHIF1A (Homo sapiens)6480464CTDcupric chloride results in decreased hydroxylation of HIF1A proteinPMID:19074761
Hif1aincreases stabilityISOHIF1A (Homo sapiens)6480464CTDcupric chloride results in increased stability of HIF1A proteinPMID:15741220 PMID:19074761
Hif1amultiple interactionsISOHIF1A (Homo sapiens)6480464CTDAscorbic Acid inhibits the reaction [cupric chloride results in decreased hydroxylation of HIF1A protein]; Ascorbic Acid inhibits the reaction [cupric chloride results in increased stability of HIF1A protein]; cupric chloride results in decreased hydroxylation of and results in decreased degradation of HIF1A proteinPMID:15741220 PMID:19074761
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