GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hif1a | decreases expression | EXP | | 6480464 | CTD | Doxorubicin results in decreased expression of HIF1A mRNA | PMID:29653124 | Hif1a | increases expression | EXP | | 6480464 | CTD | Doxorubicin results in increased expression of HIF1A protein | PMID:17531194 PMID:35667395 | Hif1a | multiple interactions | EXP | | 6480464 | CTD | [Doxorubicin co-treated with zinc chloride] results in decreased expression of HIF1A mRNA; [tricarbonyldichlororuthenium (II) dimer co-treated with Doxorubicin] results in increased expression of HIF1A mRNA | PMID:19714248 PMID:21443895 | Hif1a | affects response to substance | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | HIF1A protein affects the susceptibility to Doxorubicin | PMID:16532342 PMID:16628086 | Hif1a | decreases activity | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased activity of HIF1A protein | PMID:17498666 | Hif1a | decreases expression | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | Doxorubicin results in decreased expression of HIF1A mRNA | PMID:29803840 | Hif1a | increases expression | ISO | Hif1a (Rattus norvegicus) | 6480464 | CTD | Doxorubicin results in increased expression of HIF1A protein | PMID:34392583 | Hif1a | increases expression | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased expression of HIF1A mRNA; Doxorubicin results in increased expression of HIF1A protein | PMID:17912235 PMID:32562081 | Hif1a | multiple interactions | ISO | Hif1a (Rattus norvegicus) | 6480464 | CTD | thymoquinone inhibits the reaction [Doxorubicin results in increased expression of HIF1A protein] | PMID:34392583 | Hif1a | multiple interactions | ISO | HIF1A (Homo sapiens) | 6480464 | CTD | [dimethyl sulfone co-treated with Doxorubicin] results in increased expression of HIF1A mRNA; [Doxorubicin co-treated with Deferoxamine] results in increased expression of HIF1A protein; cobaltous chloride inhibits the reaction [Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]]; dimethyl sulfone promotes the reaction [Doxorubicin results in increased expression of HIF1A mRNA]; Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]; HIF1A protein affects the reaction [[Doxorubicin co-treated with IL6 protein] results in increased expression of ABCB1 protein]; HIF1A protein affects the reaction [[Doxorubicin co-treated with IL6 protein] results in increased expression of ABCC1 protein]; HIF1A protein affects the reaction [IL6 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]; HIF1A protein affects the reaction [IL6 protein inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]; NFKB1 protein affects the reaction [Doxorubicin results in increased expression of HIF1A protein]; zinc chloride inhibits the reaction [cobaltous chloride inhibits the reaction [Doxorubicin promotes the reaction [HIPK2 protein binds to HIF1A promoter]]] | PMID:17912235 PMID:19714248 PMID:29341321 PMID:32562081 PMID:34126102 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |