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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62221
Species: Mus musculus
RGD Object: Gene
Symbol: Hif1a
Name: hypoxia inducible factor 1, alpha subunit
Acc ID: CHEBI:28216
Term: methylmercury chloride
Definition: A chlorine molecular entity that has formula CH3ClHg.
Chemical ID: MESH:C004925
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hif1adecreases expressionISOHif1a (Rattus norvegicus)6480464CTDmethylmercuric chloride results in decreased expression of HIF1A proteinPMID:31850806
Hif1amultiple interactionsISOHif1a (Rattus norvegicus)6480464CTD2-Methoxyestradiol promotes the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; cobaltous chloride inhibits the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; Cycloheximide promotes the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]; protocatechuic acid inhibits the reaction [methylmercuric chloride results in decreased expression of HIF1A protein]PMID:31850806
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